Document Detail


Hydrogen sulfide, a toxic gas with cardiovascular properties in uremia: how harmful is it?
MedLine Citation:
PMID:  21228576     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Hydrogen sulfide (H(2)S) is a poisonous gas which can be lethal. However, it is also produced endogenously, thus belonging to the family of gasotransmitters along with nitric oxide and carbon monoxide. H(2)S is in fact involved in mediating several signaling and cytoprotective functions, for example in the nervous, cardiovascular, and gastrointestinal systems, such as neuronal transmission, blood pressure regulation and insulin release, among others. When increased, it can mediate inflammation and apoptosis, with a role in shock. When decreased, it can be involved in atherosclerosis, hypertension, myocardial infarction, diabetes, sexual dysfunction, and gastric ulcer; it notably interacts with the other gaseous mediators. Cystathionine γ-lyase, cystathionine β-synthase, and 3-mercaptopyruvate sulfurtransferase are the principal enzymes involved in H(2)S production. We have recently studied H(2)S metabolism in the plasma of chronic hemodialysis patients and reported that its levels are significantly decreased. The plausible mechanism lies in the transcription inhibition of the cystathionine γ-lyase gene. The finding could be of importance considering that hypertension and high cardiovascular mortality are characteristic in these patients.
Authors:
Alessandra F Perna; Diana Lanza; Immacolata Sepe; Ilaria Raiola; Rosanna Capasso; Natale G De Santo; Diego Ingrosso
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Publication Detail:
Type:  Journal Article     Date:  2011-01-10
Journal Detail:
Title:  Blood purification     Volume:  31     ISSN:  1421-9735     ISO Abbreviation:  Blood Purif.     Publication Date:  2011  
Date Detail:
Created Date:  2011-01-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  102-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
First Division of Nephrology, Department of Clinical and Experimental Internal Medicine, Second University of Medicine, Via Pansini 5, Naples, Italy. alessandra.perna@unina2.it
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