Document Detail


Hydrogen sulfide, the third gaseous signaling molecule with cardiovascular properties, is decreased in hemodialysis patients.
MedLine Citation:
PMID:  20797558     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hydrogen sulfide, H(2)S, is the third endogenous gas with cardiovascular properties, after nitric oxide and carbon monoxide. H(2)S is a potent vasorelaxant, and its deficiency is implicated in the pathogenesis of hypertension and atherosclerosis. Cystathionine beta-synthase, cystathionine gamma-lyase, and 3-mercaptopyruvate sulfurtransferase catalyze H(2)S formation. Chronic kidney disease is characterized by high prevalence of hyperhomocysteinemia, hypertension, and high cardiovascular mortality, especially in hemodialysis patients. H(2)S levels are decreased in hemodialysis patients through transcriptional deregulation of genes encoding for the H(2)S-producing enzymes. Potential implications relate to the pathogenesis of the manifestations of the uremic syndrome, such as hypertension and atherosclerosis.
Authors:
Alessandra F Perna; Maria Grazia Luciano; Diego Ingrosso; Ilaria Raiola; Paola Pulzella; Immacolata Sepe; Diana Lanza; Eleonora Violetti; Rosanna Capasso; Cinzia Lombardi; Natale G De Santo
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation     Volume:  20     ISSN:  1532-8503     ISO Abbreviation:  J Ren Nutr     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-27     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112938     Medline TA:  J Ren Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S11-4     Citation Subset:  IM    
Copyright Information:
Copyright 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
Affiliation:
First Division of Nephrology, Department of Clinical and Experimental Internal Medicine, Second University of Medicine, Naples, Italy. alessandra.perna@unina2.it
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MeSH Terms
Descriptor/Qualifier:
Cardiovascular Diseases / etiology
Cystathionine beta-Synthase / metabolism
Cystathionine gamma-Lyase / metabolism
Humans
Hydrogen Sulfide / blood*,  metabolism
Hyperhomocysteinemia / etiology
Hypertension / etiology
Kidney Failure, Chronic / blood*,  complications
Renal Dialysis*
Sulfurtransferases / metabolism
Uremia / blood,  enzymology
Vasodilator Agents*
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 7783-06-4/Hydrogen Sulfide; EC 2.8.1.-/Sulfurtransferases; EC 2.8.1.2/3-mercaptopyruvate sulphurtransferase; EC 4.2.1.22/Cystathionine beta-Synthase; EC 4.4.1.1/Cystathionine gamma-Lyase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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