Document Detail


Hydrogen sulfide modulates the release of nitric oxide and VEGF in human keratinocytes.
MedLine Citation:
PMID:  22842066     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hydrogen sulphide (H(2)S) is a novel signaling molecule with both pro- or anti-inflammatory effect. The present study aimed to: i- characterize the in vitro effects of H(2)S on human keratinocyte's proliferation and death; ii- investigate the ability of H(2)S to modulate VEGF and NO production; iii- examine the intracellular signaling pathways involved in VEGF and NO modulatory effect. We found that exogenous application of H(2)S (NaHS and GYY4137 as H(2)S donors) significantly enhances NO through increase of iNOS, in a manner Akt-dependent. The increment in NO down-regulates ERK1/2 activation thereby resulting in the decrease of VEGF release. We suggest that H(2)S-releasing agents may be promising therapeutics for chronic inflammatory disorders of the skin, i.e. psoriasis, in which NO increases as well as anti-VEGF treatments have been suggested to be novel effective approaches.
Authors:
Stefania Merighi; Stefania Gessi; Katia Varani; Debora Fazzi; Pier Andrea Borea
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-26
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  -     ISSN:  1096-1186     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Clinical and Experimental Medicine, Pharmacology Section and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Via Fossato di Mortara, 17/19, 44100, Ferrara, Italy.
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