| Hydrogen sulfide-mediated myocardial pre- and post-conditioning. | |
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MedLine Citation:
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PMID: 21373204 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Coronary artery disease is a major cause of morbidity and mortality in the Western world. Acute myocardial infarction, resulting from coronary artery atherosclerosis, is a serious and often fatal consequence of coronary artery disease, resulting in cell death in the myocardium. Pre- and post-conditioning of the myocardium are two treatment strategies that reduce the amount of cell death significantly. Hydrogen sulfide has recently been identified as a potent cardioprotective signaling molecule, which is a highly effective pre- and post-conditioning agent. The cardioprotective signaling pathways involved in hydrogen sulfide-based pre- and post-conditioning will be explored in this article. |
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Authors:
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Benjamin L Predmore; David J Lefer |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Expert review of clinical pharmacology Volume: 4 ISSN: 1751-2441 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-3-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101278296 Medline TA: Expert Rev Clin Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: 83-96 Citation Subset: - |
Affiliation:
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Department of Surgery, Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 HL092141-04//NHLBI NIH HHS; R01 HL093579-03//NHLBI NIH HHS |
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