Document Detail

Hydrogen sulfide-mediated myocardial pre- and post-conditioning.
MedLine Citation:
PMID:  21373204     Owner:  NLM     Status:  MEDLINE    
Coronary artery disease is a major cause of morbidity and mortality in the Western world. Acute myocardial infarction, resulting from coronary artery atherosclerosis, is a serious and often fatal consequence of coronary artery disease, resulting in cell death in the myocardium. Pre- and post-conditioning of the myocardium are two treatment strategies that reduce the amount of cell death significantly. Hydrogen sulfide has recently been identified as a potent cardioprotective signaling molecule, which is a highly effective pre- and post-conditioning agent. The cardioprotective signaling pathways involved in hydrogen sulfide-based pre- and post-conditioning will be explored in this article.
Benjamin L Predmore; David J Lefer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert review of clinical pharmacology     Volume:  4     ISSN:  1751-2441     ISO Abbreviation:  Expert Rev Clin Pharmacol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2012-01-04     Completed Date:  2012-09-04     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  101278296     Medline TA:  Expert Rev Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  83-96     Citation Subset:  IM    
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MeSH Terms
Cardiotonic Agents / metabolism*,  therapeutic use
Coronary Vessels / metabolism
Hydrogen Sulfide / metabolism*,  therapeutic use
Ischemic Postconditioning* / methods
Ischemic Preconditioning, Myocardial* / methods
Myocardial Reperfusion Injury / drug therapy,  metabolism
Myocardium / metabolism*
Signal Transduction / physiology
Grant Support
1R01 HL093579-01A1/HL/NHLBI NIH HHS; 5R01 HL092141-02/HL/NHLBI NIH HHS; R01 HL092141/HL/NHLBI NIH HHS; R01 HL092141-04/HL/NHLBI NIH HHS; R01 HL093579/HL/NHLBI NIH HHS; R01 HL093579-03/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Cardiotonic Agents; YY9FVM7NSN/Hydrogen Sulfide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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