| Hydrogen sulfide facilitates carotid sinus baroreflex in anesthetized rats. | |
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MedLine Citation:
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PMID: 16490164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To study effects of hydrogen sulfide (H2S) on the carotid sinus baroreflex (CSB). METHODS: The functional curve of the carotid sinus baroreflex was measured by recording changes in arterial pressure in anesthetized male rats with perfused carotid sinus. RESULTS: H2S (derived from sodium hydrosulfide) at concentrations of 25, 50, and 100 micromol/L facilitated the CSB, shifting the functional curve of the baroreflex downward and to the left. There was a marked increase in peak slope (PS) and reflex decrease in blood pressure (RD). Effects were concentration-dependent. Pretreatment with glibenclamide (20 micromol/L), a K(ATP) channel blocker, abolished the above effects of H2S on CSB. Pretreatment with Bay K8644 (an agonist of calcium channels; 500 nmol/L) eliminated the effect of H2S on CSB. An inhibitor of cystathionine gamma-lyase (CSE), DL-propargylglycine (PPG; 200 micromol/L), inhibited CSB in male rats and shifted the functional curve of the baroreflex upward and to the right. CONCLUSION: These data suggest that exogenous H2S exerts a facilitatory role on isolated CSB through opening K(ATP) channels and further closing the calcium channels in vascular smooth muscle. Endogenous H2S may activate the activity of the CSB in vivo. |
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Authors:
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Lin Xiao; Yu-ming Wu; Hao Zhang; Yi-xian Liu; Rui-rong He |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta pharmacologica Sinica Volume: 27 ISSN: 1671-4083 ISO Abbreviation: Acta Pharmacol. Sin. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-21 Completed Date: 2006-10-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100956087 Medline TA: Acta Pharmacol Sin Country: China |
Other Details:
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Languages: eng Pagination: 294-8 Citation Subset: IM |
Affiliation:
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Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
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pharmacology Alkynes / pharmacology Animals Baroreflex / drug effects* Blood Pressure / drug effects Calcium Channel Agonists / pharmacology Carotid Sinus / drug effects, physiology* Cystathionine gamma-Lyase / antagonists & inhibitors Glyburide / pharmacology Glycine / analogs & derivatives, pharmacology Hydrogen Sulfide / pharmacology* Male Potassium Channel Blockers / pharmacology Rats Rats, Sprague-Dawley Sulfides / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Alkynes; 0/Calcium Channel Agonists; 0/Potassium Channel Blockers; 0/Sulfides; 10238-21-8/Glyburide; 16721-80-5/sodium bisulfide; 56-40-6/Glycine; 64165-64-6/propargylglycine; 71145-03-4/3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 7783-06-4/Hydrogen Sulfide; EC 4.4.1.1/Cystathionine gamma-Lyase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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