| Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration. | |
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MedLine Citation:
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PMID: 22772154 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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An emerging aspect of redox signaling is the pathway mediated by electrophilic byproducts, such as nitrated cyclic nucleotide (for example, 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP)) and nitro or keto derivatives of unsaturated fatty acids, generated via reactions of inflammation-related enzymes, reactive oxygen species, nitric oxide and secondary products. Here we report that enzymatically generated hydrogen sulfide anion (HS(-)) regulates the metabolism and signaling actions of various electrophiles. HS(-) reacts with electrophiles, best represented by 8-nitro-cGMP, via direct sulfhydration and modulates cellular redox signaling. The relevance of this reaction is reinforced by the significant 8-nitro-cGMP formation in mouse cardiac tissue after myocardial infarction that is modulated by alterations in HS(-) biosynthesis. Cardiac HS(-), in turn, suppresses electrophile-mediated H-Ras activation and cardiac cell senescence, contributing to the beneficial effects of HS(-) on myocardial infarction-associated heart failure. Thus, this study reveals HS(-)-induced electrophile sulfhydration as a unique mechanism for regulating electrophile-mediated redox signaling. |
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Authors:
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Motohiro Nishida; Tomohiro Sawa; Naoyuki Kitajima; Katsuhiko Ono; Hirofumi Inoue; Hideshi Ihara; Hozumi Motohashi; Masayuki Yamamoto; Makoto Suematsu; Hitoshi Kurose; Albert van der Vliet; Bruce A Freeman; Takahiro Shibata; Koji Uchida; Yoshito Kumagai; Takaaki Akaike |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-01 |
Journal Detail:
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Title: Nature chemical biology Volume: - ISSN: 1552-4469 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101231976 Medline TA: Nat Chem Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1] Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. [2] Department of Drug Discovery and Evolution, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. [3]. |
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