| Hydrogen sulfide and Asthma. | |
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MedLine Citation:
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PMID: 21666034 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Asthma is a chronic inflammatory disease with hyper-responsive bronchoconstriction and airway remodeling, leading to extensive airway narrowing. The regulation of airway responsiveness and inflammation by endogenous hydrogen sulfide (H2S) during the pathogenic development of asthma has been suggested. H2S can be produced in the lung and airway tissues via the actions of two H2S-generating enzymes, cystathionine beta-synthase (CBS) and/or cystathionine gamma-lyase (CSE). The abnormal metabolism and function of H2S have been reported in experimental animals with asthma, especially ovalbumin (OVA)-induced rat or mouse models. In patients with asthma, serum H2S level decreased significantly. Supplementation of exogenous H2S has been shown to mitigate the severity of asthma in experimental animals. It is hypothesized that decreased H2S production in the lung and airway tissues may be used as an early detection biomarker, and H2S-based therapy would represent a new line of treatment strategy, for asthma. Major challenges for establishing the diagnostic and treatment values of H2S include the differential expression of CSE and CBS along the airway and their changes during asthma, the effects of H2S on bronchoconstriction and airway remodeling as well as the underlying mechanisms, and the detection of the changes in H2S levels in airway tissues and in exhaled air. |
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Authors:
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Peipei Wang; Gensheng Zhang; Taddese Wondimu; Brian Ross; Rui Wang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-10 |
Journal Detail:
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Title: Experimental physiology Volume: - ISSN: 1469-445X ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Lakehead University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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