Document Detail


Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats.
MedLine Citation:
PMID:  19596825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Protective effect of hydrogen (H(2)) gas on cardiac ischemia-reperfusion (I/R) injury has been demonstrated previously. This study was designed to test the hypothesis that hydrogen-rich saline (saline saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ischemia (30 min) and reperfusion (24 h) injury in rats. Adult male Sprague-Dawley rats underwent 30-min occlusion of the left anterior descending (LAD) coronary artery and 24-h reperfusion. Intraperitoneal injection of hydrogen-rich saline before reperfusion significantly decreased plasma and myocardium malondialdehyde (MDA) concentration, decreased cardiac cell apoptosis, and myocardial 8-hydroxydeoxyguanosine (8-OHdG) in area at risk zones (AAR), suppressed the activity of caspase-3, and reduced infarct size. The heart function parameters including left ventricular systolic pressure (LVSP), left ventricular diastolic pressure (LVDP), +(dP/dt)(max) and -(dP/dt)(max) were also significantly improved 24 h after reperfusion. It is concluded that hydrogen-rich saline is a novel, simple, safe, and effective method to attenuate myocardial I/R injury.
Authors:
Qiang Sun; Zhimin Kang; Jianmei Cai; Wenwu Liu; Yun Liu; John H Zhang; Petar J Denoble; Hengyi Tao; Xuejun Sun
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-13
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  234     ISSN:  1535-3699     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-24     Completed Date:  2009-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1212-9     Citation Subset:  IM    
Affiliation:
Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, P. R. China. sunxjk@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects
Blood Pressure / drug effects
Cardiotonic Agents / pharmacology*
Caspase 3 / metabolism
Deoxyguanosine / analogs & derivatives,  metabolism
Hydrogen / pharmacology*
Male
Malondialdehyde / metabolism
Myocardial Reperfusion Injury / physiopathology,  prevention & control*
Myocardium / metabolism*
Random Allocation
Rats
Rats, Sprague-Dawley
Sodium Chloride / pharmacology*
Ventricular Dysfunction, Left / drug therapy
Chemical
Reg. No./Substance:
0/8-hydroxy-2'-deoxyguanosine; 0/Cardiotonic Agents; 1333-74-0/Hydrogen; 542-78-9/Malondialdehyde; 7647-14-5/Sodium Chloride; 961-07-9/Deoxyguanosine; EC 3.4.22.-/Caspase 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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