Document Detail


Hydrogen peroxide mutagenicity towards Salmonella typhimurium.
MedLine Citation:
PMID:  2572065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In bioassays conducted under controlled, comparable conditions, weak direct mutagenicity responses were observed for hydrogen peroxide in the standard (Ames test) agar plate incorporation bioassay with Salmonella typhimurium strains TA97, TA98, TA102, and TA1537, in a 20 min preincubation test with strains TA97, TA98, TA100, TA102, TA1537, and TA1538, and in a liquid incubation modification using strain TA1537. These results conclusively demonstrate that hydrogen peroxide is a weak mutagen, especially in strains that are sensitive to oxidative damage under suitable bioassay conditions.
Authors:
S M Kensese; L L Smith
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Teratogenesis, carcinogenesis, and mutagenesis     Volume:  9     ISSN:  0270-3211     ISO Abbreviation:  Teratog., Carcinog. Mutagen.     Publication Date:  1989  
Date Detail:
Created Date:  1989-11-20     Completed Date:  1989-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100917     Medline TA:  Teratog Carcinog Mutagen     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  211-8     Citation Subset:  IM    
Affiliation:
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77550.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Hydrogen Peroxide / administration & dosage,  toxicity*
Liver / enzymology
Mutagenicity Tests
Mutagens*
Rats
Rats, Inbred Strains
Salmonella typhimurium / drug effects
Chemical
Reg. No./Substance:
0/Mutagens; 7722-84-1/Hydrogen Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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