Document Detail

Hydrogen peroxide induces hyphal differentiation in Candida albicans.
MedLine Citation:
PMID:  18791036     Owner:  NLM     Status:  MEDLINE    
In this study, we demonstrate that hyphal differentiation is induced by the subtoxic concentration of exogenous H(2)O(2) in Candida albicans. This finding is confirmed by the changing intracellular concentration of H(2)O(2). In order to induce the same level of differentiation, low concentrations of exogenous H(2)O(2) are required for the null mutants of the thiol-specific antioxidant and catalase, while higher concentrations are needed for cells treated with ascorbic acid, an antioxidant chemical.
Olviyani Nasution; Kavitha Srinivasa; Minsun Kim; Yeo-Jung Kim; Wankee Kim; Woojin Jeong; Wonja Choi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-12
Journal Detail:
Title:  Eukaryotic cell     Volume:  7     ISSN:  1535-9786     ISO Abbreviation:  Eukaryotic Cell     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-05     Completed Date:  2008-11-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  101130731     Medline TA:  Eukaryot Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2008-11     Citation Subset:  IM    
Science Building A, Room 211, Ewha Womans University, Seoul 120-750, South Korea.
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MeSH Terms
Ascorbic Acid / metabolism
Candida albicans / cytology,  genetics,  physiology*
Hydrogen Peroxide / metabolism*
Hyphae / cytology,  genetics,  physiology*
Reg. No./Substance:
50-81-7/Ascorbic Acid; 7722-84-1/Hydrogen Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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