| Hydrogen peroxide enhances phagocytosis of Pseudomonas aeruginosa in hyperoxia. | |
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MedLine Citation:
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PMID: 21261440 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Mechanical ventilation with hyperoxia is a necessary treatment for patients with respiratory distress. However, patients on mechanical ventilation have increased susceptibility to infection. Studies including ours have shown that reactive oxygen species (ROS), generated by exposure to prolonged hyperoxia, can cause a decrease in the phagocytic activity of alveolar macrophages. Hydrogen peroxide (H(2)O(2)) is a form of ROS generated under hyperoxic conditions. In this study, we examined whether treatment with H(2)O(2) directly affects macrophage phagocytic ability in RAW 264.7 cells that were exposed to either 21% O(2) (room air) or 95% O(2) (hyperoxia). Moderate concentrations (ranging from 10 to 250 µM) of H(2)O(2) significantly enhanced macrophage phagocytic activity and restored hyperoxia-suppressed phagocytosis through attenuation of hyperoxia-induced disorganization of actin cytoskeleton and actin oxidation. These results indicate that H(2)O(2) at low-moderate concentrations can be beneficial to host immune responses by improving macrophage phagocytic activity. |
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Authors:
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Binh D Phan; Maria Entezari; Richard A Lockshin; Diana C Bartelt; Lin L Mantell |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-24 |
Journal Detail:
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Title: Journal of immunotoxicology Volume: - ISSN: 1547-6901 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101201960 Medline TA: J Immunotoxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pharmaceutical Sciences, St. John's University College of Pharmacy, Queens, NY, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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