Document Detail


Hydrogen is neuroprotective and preserves cerebrovascular reactivity in asphyxiated newborn pigs.
MedLine Citation:
PMID:  20657346     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hydrogen (H2) has been reported to neutralize toxic reactive oxygen species. Oxidative stress is an important mechanism of neuronal damage after perinatal asphyxia. We examined whether 2.1% H2-supplemented room air (H2-RA) ventilation would preserve cerebrovascular reactivity (CR) and brain morphology after asphyxia/reventilation (A/R) in newborn pigs. Anesthetized, ventilated piglets were assigned to one of the following groups: A/R with RA or H2-RA ventilation (A/R-RA and A/R-H2-RA; n = 8 and 7, respectively) and respective time control groups (n = 9 and 7). Asphyxia was induced by suspending ventilation for 10 min, followed by reventilation with the respective gases for 4 h. After euthanasia, the brains were processed for neuropathological examination. Pial arteriolar diameter changes to graded hypercapnia (5-10% CO2 inhalation), and NMDA (10(-4) M) were determined using the closed cranial window/intravital microscopy before and 1 h after asphyxia. Neuropathology revealed that H2-RA ventilation significantly reduced neuronal injury induced by A/R in virtually all examined brain regions including the cerebral cortex, the hippocampus, basal ganglia, cerebellum, and the brainstem. Furthermore, H2-RA ventilation significantly increased CR to hypercapnia after A/R (% vasodilation was 23 ± 4% versus 41 ± 9%, p < 0.05). H2-RA ventilation did not affect reactive oxygen species-dependent CR to NMDA. In summary, H2-RA could be a promising approach to reduce the neurologic deficits after perinatal asphyxia.
Authors:
Ferenc Domoki; Orsolya Oláh; Aliz Zimmermann; István Németh; Valéria Tóth-Szuki; Marietta Hugyecz; Péter Temesvári; Ferenc Bari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  68     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-13     Completed Date:  2011-02-01     Revised Date:  2013-03-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  387-92     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of Szeged School of Medicine, Szeged H-6720, Hungary. domoki@phys.szote.u-szeged.hu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Asphyxia Neonatorum / physiopathology*
Blood Chemical Analysis
Brain* / blood supply,  drug effects,  metabolism
Cerebrovascular Circulation / drug effects*
Disease Models, Animal*
Hemodynamics
Humans
Hydrogen / pharmacology*
Hypercapnia / metabolism
Infant, Newborn
Neuroprotective Agents / pharmacology*
Swine
Chemical
Reg. No./Substance:
0/Neuroprotective Agents; 1333-74-0/Hydrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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