Document Detail

Hydrogen-deuterium exchange and selective labeling of deprotonated amino acids and peptides in the gas phase.
MedLine Citation:
PMID:  18067298     Owner:  NLM     Status:  MEDLINE    
Hydrogen-deuterium exchange reactions of deprotonated amino acids and small peptides were studied. Selective labeling can be carried out at the alpha-amino group of lysine (2 of 4 labile hydrogens undergo exchange with CF3CH2OD) and the guanidine side chain of arginine (3 of 6 labile hydrogens undergo exchange with CH3CH2OD and C6H5CH2OD). Differential labeling of peptides also was accomplished, and the extent of H/D exchange is dependent on the amino acids which are present as well as their order in the chain.
Zhixin Tian; Lev Lis; Steven R Kass
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-12-08
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  130     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-02     Completed Date:  2008-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8-9     Citation Subset:  IM    
Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
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MeSH Terms
Amino Acids / chemistry*
Deuterium Exchange Measurement*
Gases / chemistry
Isotope Labeling / methods*
Peptides / chemistry*
Reg. No./Substance:
0/Amino Acids; 0/Gases; 0/Peptides

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