Document Detail


Hydrogen sulfide and its modulation in arterial hypertension and atherosclerosis.
MedLine Citation:
PMID:  20545623     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Apart from nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide (H₂S) is the third gaseous mediator in mammals. H₂S is synthesized from L-cysteine by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), or by sequential action of alanine aminotransferase and 3-mercaptopyruvate sulfurtransferase. In the cardiovascular system, H₂S is involved in the regulation of vascular tone and blood pressure, inhibits atherogenesis, and protects myocardium from ischemia-reperfusion injury. Recently, the first organic, water-soluble H₂S donor, GYY4137, has been synthesized. In addition, H₂S-releasing derivatives of several currently used drugs such as sildenafil, diclofenac, aspirin and mesalamine were obtained. Such compounds may be used in the future treatment of cardiovascular diseases. In this article, I describe the role of H₂S in the regulation of blood pressure and in the pathogenesis of arterial hypertension and atherosclerosis which are two most common cardiovascular disorders.
Authors:
J Bełtowski; A Jamroz-Wiśniewska; D Tokarzewska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular & hematological agents in medicinal chemistry     Volume:  8     ISSN:  1875-6182     ISO Abbreviation:  Cardiovasc Hematol Agents Med Chem     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-06     Completed Date:  2011-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101266881     Medline TA:  Cardiovasc Hematol Agents Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  173-86     Citation Subset:  IM    
Affiliation:
Department of Pathophysiology, Medical University, Lublin, Poland. jerzy.beltowski@am.lublin.pl
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MeSH Terms
Descriptor/Qualifier:
Animals
Atherosclerosis / metabolism*
Blood Pressure
Body Fluids / metabolism
Humans
Hydrogen Sulfide / chemistry,  metabolism*
Hypertension / metabolism*
Mice
Rats
Signal Transduction
Chemical
Reg. No./Substance:
7783-06-4/Hydrogen Sulfide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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