Document Detail

Hydrogen sulfide and oxygen sensing in the cardiovascular system.
MedLine Citation:
PMID:  19803742     Owner:  NLM     Status:  MEDLINE    
Vertebrate cardiorespiratory homeostasis is inextricably dependent upon specialized cells that provide feedback on oxygen status in the tissues, blood, and on occasion, environment. These "oxygen sensing" cells include chemoreceptors and oxygen-sensitive chromaffin cells that initiate cardiorespiratory reflexes, vascular smooth muscle cells that adjust perfusion to metabolism or ventilation, and other cells that condition themselves in response to episodic hypoxia. Identification of how these cells sense oxygen and transduce this into the appropriate physiological response has enormous clinical applicability, but despite intense research there is no consensus regarding the initial hypoxia-effector coupling mechanism. This review examines an alternative mechanism of oxygen sensing using oxidation of endogenously produced hydrogen sulfide (H(2)S) as the O(2)-sensitive couple. Support for this hypothesis includes the similarity of effects of hypoxia and H(2)S on a variety of tissues, augmentation of hypoxic responses by precursors of H(2)S production and their inhibition by inhibitors of H(2)S synthesis, and the rapid consumption of H(2)S by O(2) in the range of intracellular/mitochondrial Po(2). These studies also indicate that, under normoxic conditions, it is doubtful that free H(2)S has longer than a transient existence in tissue or extracellular fluid.
Kenneth R Olson; Nathan L Whitfield
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  12     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1219-34     Citation Subset:  IM    
Indiana University School of Medicine, South Bend Center, South Bend, Indiana 46617, USA.
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MeSH Terms
Air Pollutants / metabolism
Blood Vessels / metabolism
Cardiovascular System / metabolism*
Carotid Body / cytology,  metabolism
Cell Hypoxia / physiology
Chemoreceptor Cells / cytology,  metabolism*
Chromaffin Cells / metabolism
Homeostasis / physiology*
Hydrogen Sulfide / metabolism*
Ischemic Preconditioning, Myocardial
Oxygen / metabolism*
Signal Transduction / physiology
Reg. No./Substance:
0/Air Pollutants; 7782-44-7/Oxygen; 7783-06-4/Hydrogen Sulfide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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