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Hydrogen Protects Mice From Dermatitis Caused by Local Radiation.
MedLine Citation:
PMID:  23273331     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Background: Radiation therapy produced unwanted side effect on normal tissues, such as radiodermatitis. Hydrogen was previously shown capable of radiation protective in both animals and cell cultures. The effect of hydrogen was now to be investigated on radiation-induced cutaneous. Objective: Development of dermatitis is a frequent side effect of radiotherapy of patients with head-and-neck cancer. Here we analyzed the radioprotective efficacy of hydrogen under conditions of local, single dose or fractionated radiation treatment, and its possible molecular mechanisms. Methods: Mice received either single-dose or fractioned irradiation of the head-and-neck area with or without subcutaneous injection of hydrogen solution before irradiation. In vitro, the effect of hydrogen medium on radiation-induced cell viability , apoptosis and biochemical assays was measured. Result: hydrogen significantly reduced the severity of dermatitis, accelerated tissue recovery, and reduced the extent of radiation induced weight loss in mice after a single dose of 15 or 20 Gy but not 25 Gy of radiation. Hydrogen was also protective from cumulative doses of 30 Gy delivered in three fractions, respectively. Hydrogen also protect HaCaT cells from radiation-induced injury, it could significantly inhibit ionizing injury. Conclusion: These results suggest that hydrogen has a positive effect on acute radiodermatitis.
Authors:
Ke Mei; Sanhu Zhao; Liren Qian; Bailong Li; Jin Ni; Jianming Cai
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-31
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  -     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Radiation Medicine,Faculty of Naval Medicine,2nd Medical University,Shanghai,R.P.China, Shanghai, ShangHai, China, 200090.
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