Document Detail


Hydrodynamic thickening of lubricating fluid layer beneath sliding mesothelial tissues.
MedLine Citation:
PMID:  18367193     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The delicate mesothelial surfaces of the pleural space and other serosal cavities slide relative to each, lubricated by pleural fluid. In the absence of breathing motion, differences between lung and chest wall shape could eventually cause the lungs and chest wall to come into contact. Whether sliding motion keeps lungs and chest wall separated by a continuous liquid layer is not known. To explore the effects of hydrodynamic pressures generated by mesothelial sliding, we measured the thickness of the liquid layer beneath the peritoneal surface of a 3-cm disk of rat abdominal wall under a normal stress of 2 cm H2O sliding against a glass plate rotating at 0-1 rev/s. Thickness of the lubricating layer was determined microscopically from the appearance of fluorescent microspheres adherent to the tissue and glass. Usually, fluid thickness near the center of the tissue disk increased with the onset of glass rotation, increasing to 50-200 microm at higher rotation rates, suggesting hydrodynamic pumping. However, thickness changes often differed substantially among tissue samples and between clockwise and counter-clockwise rotation, and sometimes thickness decreased with rotation, suggesting that topographic features of the tissue are important in determining global hydrodynamic effects. We conclude that mesothelial sliding induces local hydrodynamic pressure gradients and global hydrodynamic pumping that typically increases the thickness of the lubricating fluid layer, moving fluid against the global pressure gradient. A similar phenomenon could maintain fluid continuity in the pleural space, reducing frictional force and shear stress during breathing.
Authors:
Judy L Lin; Taraneh Moghani; Ben Fabry; James P Butler; Stephen H Loring
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-03-25
Journal Detail:
Title:  Journal of biomechanics     Volume:  41     ISSN:  0021-9290     ISO Abbreviation:  J Biomech     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-14     Completed Date:  2008-09-09     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1197-205     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abdominal Wall / physiology*
Animals
Body Fluids / physiology*
Epithelium / physiology*
Male
Movement / physiology*
Peritoneum / physiology*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
HL63737/HL/NHLBI NIH HHS; R01 HL063737/HL/NHLBI NIH HHS; R01 HL063737-04A1/HL/NHLBI NIH HHS; R01 HL063737-05/HL/NHLBI NIH HHS; R01 HL063737-06/HL/NHLBI NIH HHS; R01 HL063737-07/HL/NHLBI NIH HHS
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