Document Detail

Hydrodynamic characteristics of porcine aortic valves cross-linked with glutaraldehyde and polyepoxy compounds.
MedLine Citation:
PMID:  19092670     Owner:  NLM     Status:  MEDLINE    
Porcine aortic valve (AoF) tissues cross-linked with glutaraldehyde and epoxy compounds were reported to have high anticalcification properties, but their hydrodynamic characteristics have not been evaluated. The aim of the present study was to investigate the hydrodynamic differences between porcine AoFs, cross-linked with concomitant use of an epoxy compound and glutaraldehyde, at different fixation periods. The valves were mounted on a pulsatile flow circulation mimicking a left heart. The left atrial and left ventricular pressures and mitral and aortic flows were measured at every 0.002 seconds, and the hydrodynamic factor of the valves mounted on the mitral position was estimated. Effective orifice area and the regurgitation volume, which are used as indicators of valve efficiency, failed to detect significant differences due to glutaraldehyde fixation time. In addition, the pressure gradient across the bioprosthetic valve and the variation of mitral flow also had no significant differences. The flow circuit model of the present study was mimicking of a left heart. The evaluation of the mitral valvular function with different glutaraldehyde fixation times was accomplished by relating the pressure with the flow, and by estimating the time lag between valve motion and transvalvular flow.
Aiko Soda; Ryou Tanaka; Yuuto Saida; Kazuaki Takashima; Tomohiro Hirayama; Mitsuo Umezu; Yoshihisa Yamane
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  55     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:    2009 Jan-Feb
Date Detail:
Created Date:  2009-01-13     Completed Date:  2009-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  IM    
Faculty of Agriculture, Department of Veterinary Surgery, Tokyo University of Agriculture and Technology, Saiwai-cho, Fuchu-shi, Tokyo, Japan.
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MeSH Terms
Aortic Valve / surgery
Cardiovascular Physiological Processes*
Cross-Linking Reagents*
Epoxy Compounds*
Heart Valve Prosthesis*
Materials Testing
Prosthesis Design
Reg. No./Substance:
0/Cross-Linking Reagents; 0/Epoxy Compounds; 111-30-8/Glutaral

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