Document Detail

Hydrodynamic Performance of a Prototype Bioprosthetic Valve Derived from the Pulmonary Valve of Phoca groenlandica.
MedLine Citation:
PMID:  22929892     Owner:  NLM     Status:  In-Data-Review    
Biological valves offer significant advantages over mechanical valves, and for this reason, we studied the possibility of using a new animal source such as that of Phoca groenlandica. Four aortic and four pulmonary leaflets were cut radially and their uniaxial tensile testing was evaluated. Three prototype pulmonary valves of Phoca groenlandica preserved in buffered glutaraldehyde solution 0.625% at pH 7.4 were mounted on a 19, 21, and 27 mm novel support system (stent) with heart shape commissural posts covered with polytetrafluoroethylene. The valves were tested in a steady flow system, the peak pressure gradients (PPGs) were measured, and the effective orifice areas (EOAs) were calculated for the flows of 3, 4, 5, 6, and 8 L/min. There were five different measurements for each flow variant. Aortic and pulmonary leaflets present no statistically significant difference in failure strength (p = 0.93). The PPGs across the valves for the flow of 3, 4, 5, 6, and 8 L/min for all three tested valves were low and the corresponding calculated EOAs were large. The new bioprosthetic valve derived from the pulmonary valve of Phoca groenlandica mounted on this novel support system presented a satisfactory hydrodynamic performance in a steady flow system. More research is needed before it can be considered suitable for human cardiac valve replacement.
E Andreas Agathos; Ming Shen; Witold Styrc; Stamatina Giannakopoulou; Elias Lachanas; Perikles Tomos
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  58     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  535-9     Citation Subset:  IM    
From the Department of Cardiac Surgery, Athens Medical-Psychico Clinic, Athens, Greece; Perouse Medical (Shanghai) Co, Ltd, Shanghai, China; R&D Dispositifs Medicaux Cardiovasculaire, Perouse Medical, Ivry Le Temple, France; and Department of Thoracic Surgery, Laiko Hospital, University of Athens, Athens, Greece.
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