| Hydrocortisone is associated with cell surface blebbing in cultures of human embryonic lung fibroblasts. | |
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MedLine Citation:
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PMID: 3796057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment with hydrocortisone (HC) is associated with increased cell surface blebbing of proliferatively active WI-38 and IMR-90 fibroblasts at low and high population doubling levels within the first 24 h after seeding. Time course studies show a marked decrease in blebbing after 2 days. In contrast, very old cells near the end of the population life span (greater than 96% life span completed) show blebbing which is independent of HC treatment. Since the time of increased HC-associated blebbing in cycling cell populations coincides with the time during which HC-treated cells condition the medium with a growth-stimulating (autocrine) factor, it is possible that blebbing may represent extrusion of this factor from the cells at these times. |
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Authors:
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B M Stanulis-Praeger; M A Shatos; V J Cristofalo |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 36 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 1986 Nov |
Date Detail:
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Created Date: 1987-02-17 Completed Date: 1987-02-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 243-58 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology Cell Line Cell Membrane / drug effects* Embryo, Mammalian Fibroblasts / drug effects*, ultrastructure Humans Hydrocortisone / pharmacology* Microscopy, Electron, Scanning Mitosis Organoids / ultrastructure |
| Grant Support | |
ID/Acronym/Agency:
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AG00378/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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