Document Detail


Hydrocodone excretion into breast milk: the first two reported cases.
MedLine Citation:
PMID:  17661614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hydrocodone is a narcotic that is widely used, often in nursing mothers. Although case reports suggest that hydrocodone in breast milk sometimes may be problematic for the breastfed infant, no reports exist on the amount of its excretion into breast milk. Two mothers who were taking an acetaminophen and hydrocodone combination product donated pumped milk for analysis of hydrocodone. Their infants received an estimated 3.1% and 3.7% of the maternal weight-adjusted dosage, but the absolute hydrocodone dosages were 8.58 microg/kg per day and 3.07 microg/kg per day because of the differences in the dosages ingested by their mothers. Moderate dosages of hydrocodone appear acceptable during breastfeeding, but more data are needed to determine the maximum safe dosage for nursing mothers. Neonates and preterm infants may be more susceptible than older infants to adverse effects of hydrocodone and its metabolites in breast milk.
Authors:
Philip O Anderson; Jason B Sauberan; James R Lane; Steven S Rossi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine     Volume:  2     ISSN:  1556-8342     ISO Abbreviation:  -     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-07-30     Completed Date:  2007-09-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101260777     Medline TA:  Breastfeed Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10-4     Citation Subset:  IM    
Affiliation:
Department of Pharmacy, University of California San Diego Medical Center, San Diego, California 92103-8925, USA. phanderson@ucsd.edu <phanderson@ucsd.edu>
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Area Under Curve
Dose-Response Relationship, Drug
Female
Humans
Hydrocodone / pharmacokinetics*
Infant
Infant, Newborn / metabolism*
Infant, Premature / metabolism
Milk, Human / chemistry*
Narcotics / pharmacokinetics*
Safety
Chemical
Reg. No./Substance:
0/Narcotics; 125-29-1/Hydrocodone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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