Document Detail

Hydrocephalus and mental retardation in craniosynostosis.
MedLine Citation:
PMID:  4067746     Owner:  NLM     Status:  MEDLINE    
We prospectively studied craniosynostosis, regardless of neurologic status, by cranial computed tomography or psychometric testing in 56 children. None of the 27 children with simple craniosynostosis (single or multiple suture involvement) had evidence of hydrocephalus on CT scan. Of the 24 patients with simple craniosynostosis who underwent psychometric testing, 17 were of average intelligence; six were in the low average range. The single mentally retarded child had a history of severe perinatal asphyxia. Hydrocephalus occurred more frequently (five of 23 cases) in children with complex craniosynostosis syndromes, including Pfeiffer syndrome, Crouzon syndrome, and kleeblattschädel deformity. More striking than hydrocephalus, however, was the finding of dysmorphic ventricular dilation in eight patients, including the three children with Apert syndrome and four with Crouzon syndrome. Nineteen of the 25 children with complex craniosynostosis syndromes receiving psychometric testing were of normal intelligence. Four children with borderline normal intelligence had either hydrocephalus or ventricular dilation. The two children with mental retardation were sisters with Crouzon syndrome whose family included other retarded individuals. This study indicates that the incidence of hydrocephalus and mental retardation in craniosynostosis is lower than reported previously.
M J Noetzel; J L Marsh; H Palkes; M Gado
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  107     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-01-21     Completed Date:  1986-01-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  885-92     Citation Subset:  AIM; IM    
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MeSH Terms
Acrocephalosyndactylia / complications
Child, Preschool
Craniofacial Dysostosis / complications
Craniosynostoses / complications*,  psychology,  radiography
Hydrocephalus / complications*,  psychology,  radiography
Intelligence Tests
Mental Retardation / complications*,  psychology
Neurologic Examination
Prospective Studies
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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