| Hydrocarbon chain packing modes in lipids: effect of altered sub-cell dimensions and chain rotation. | |
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MedLine Citation:
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PMID: 2095989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The lateral hydrocarbon chain packing modes of lipids have been described in terms of specific hydrocarbon sub-cells as deduced from single crystal structural studies. To understand the changes in hydrocarbon chain packing in lipid bilayers induced by variations in temperature, hydration, ion-binding, etc., we have examined the effect on the calculated X-ray diffraction pattern of (a) systematic variations in the dimensions of the hydrocarbon sub-cell and (b) the effect of chain rotation at fixed lattice sites. For the O perpendicular (orthorhombic) sub-cell, the a and b sub-cell parameters were varied from as = 4.96 to 4.85 A and bs = 7.42 to 8.40 A in six steps and the positions (s = 2 sin theta/lambda) and intensities (Icalc = F2) of the strong sub-cell reflections calculated. In this way, the conversion of the O perpendicular sub-cell (with either fixed chain orientations or simulated chain rotation) to the hexagonal (H) sub-cell (with chain rotation) was followed. Notably, the two strong reflections characteristic of the O perpendicular sub-cell at 4.12 A (110) and 3.71 A (020) show progressive shifts in position and intensity, finally merging to give the strong (O1O) reflection at 4.2 A characteristic of the hexagonal sub-cell. Similar calculations were performed for the orthorhombic (O' perpendicular) and monoclinic (M parallel) sub-cells. This approach can be used to analyze changes in the X-ray diffraction data due to modifications of the hydrocarbon chain packing modes characteristic of simple and complex lipids. |
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Authors:
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P R Maulik; M J Ruocco; G G Shipley |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Chemistry and physics of lipids Volume: 56 ISSN: 0009-3084 ISO Abbreviation: Chem. Phys. Lipids Publication Date: 1990 Dec |
Date Detail:
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Created Date: 1991-07-12 Completed Date: 1991-07-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0067206 Medline TA: Chem Phys Lipids Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 123-33 Citation Subset: IM |
Affiliation:
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Department of Biophysics, Boston University School of Medicine, Housman Medical Research Center, MA 02118. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Hydrocarbons
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chemistry* Lipids / chemistry* Models, Molecular Molecular Conformation Rotation X-Ray Diffraction |
| Grant Support | |
ID/Acronym/Agency:
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HL-07291/HL/NHLBI NIH HHS; HL-26335/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hydrocarbons; 0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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