Document Detail


Hydrocarbon chain packing modes in lipids: effect of altered sub-cell dimensions and chain rotation.
MedLine Citation:
PMID:  2095989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The lateral hydrocarbon chain packing modes of lipids have been described in terms of specific hydrocarbon sub-cells as deduced from single crystal structural studies. To understand the changes in hydrocarbon chain packing in lipid bilayers induced by variations in temperature, hydration, ion-binding, etc., we have examined the effect on the calculated X-ray diffraction pattern of (a) systematic variations in the dimensions of the hydrocarbon sub-cell and (b) the effect of chain rotation at fixed lattice sites. For the O perpendicular (orthorhombic) sub-cell, the a and b sub-cell parameters were varied from as = 4.96 to 4.85 A and bs = 7.42 to 8.40 A in six steps and the positions (s = 2 sin theta/lambda) and intensities (Icalc = F2) of the strong sub-cell reflections calculated. In this way, the conversion of the O perpendicular sub-cell (with either fixed chain orientations or simulated chain rotation) to the hexagonal (H) sub-cell (with chain rotation) was followed. Notably, the two strong reflections characteristic of the O perpendicular sub-cell at 4.12 A (110) and 3.71 A (020) show progressive shifts in position and intensity, finally merging to give the strong (O1O) reflection at 4.2 A characteristic of the hexagonal sub-cell. Similar calculations were performed for the orthorhombic (O' perpendicular) and monoclinic (M parallel) sub-cells. This approach can be used to analyze changes in the X-ray diffraction data due to modifications of the hydrocarbon chain packing modes characteristic of simple and complex lipids.
Authors:
P R Maulik; M J Ruocco; G G Shipley
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  56     ISSN:  0009-3084     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-07-12     Completed Date:  1991-07-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  123-33     Citation Subset:  IM    
Affiliation:
Department of Biophysics, Boston University School of Medicine, Housman Medical Research Center, MA 02118.
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MeSH Terms
Descriptor/Qualifier:
Hydrocarbons / chemistry*
Lipids / chemistry*
Models, Molecular
Molecular Conformation
Rotation
X-Ray Diffraction
Grant Support
ID/Acronym/Agency:
HL-07291/HL/NHLBI NIH HHS; HL-26335/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Hydrocarbons; 0/Lipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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