| Hydrazinopropionic acid: a new inhibitor of aminobutyrate transaminase and glutamate decarboxylase. | |
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MedLine Citation:
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PMID: 18561486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper deals with the synthesis of 3-pyrazolidone and the biochemical action of hydrazinopropionic acid. The latter compound is formed upon alkaline hydrolysis of 3-pyrazolidone. Hydrazinopropionic acid was found in vitro to be a very potent inhibitor of bacterial aminobutyrate transaminase as well as of aminobutyrate transaminase and glutamate decarboxylase from mouse brain. This inhibition was shown to occur despite the presence of high concentrations of pyridoxal phosphate in the incubation media. Injections of 20 mg hydrazinopropionic acid/kg into mice resulted in complete inhibition of aminobutyrate transaminase in brain and approximately 20 per cent inactivation of glutamate decarboxylase. This inhibition could not be prevented or antagonized by administration of pyridoxine to the animals. Addition of pyridoxal phosphate to homogenates of brain from animals treated with hydrazinopropionic acid also failed to reactivate the enzymes. The tentative conclusion reached from these results is that hydrazinopropionic acid has inhibitory action because of its close similarity to GABA with respect to molecular size, structural configuration and molecular charge distribution. This can be demonstrated by comparing a Dreiding model of hydrazinopropionic acid with that representing GABA. |
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Authors:
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N M van Gelder |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurochemistry Volume: 15 ISSN: 0022-3042 ISO Abbreviation: J. Neurochem. Publication Date: 1968 Aug |
Date Detail:
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Created Date: 2008-06-19 Completed Date: 2008-08-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: England |
Other Details:
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Languages: eng Pagination: 747-57 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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4-Aminobutyrate Transaminase
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metabolism* Animals Brain / cytology, drug effects, metabolism* Dose-Response Relationship, Drug Enzyme Inhibitors / pharmacology* Glutamate Decarboxylase / metabolism* Glycine / analogs & derivatives*, analysis, pharmacology Mice Pyridoxine / pharmacology Time Factors Vitamin B Complex / pharmacology gamma-Aminobutyric Acid / metabolism, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 12001-76-2/Vitamin B Complex; 14150-64-2/hydrazinoacetic acid; 56-12-2/gamma-Aminobutyric Acid; 56-40-6/Glycine; 65-23-6/Pyridoxine; EC 2.6.1.19/4-Aminobutyrate Transaminase; EC 4.1.1.15/Glutamate Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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