Document Detail

Hybrid systems through natural product leads: an approach towards new molecular entities.
MedLine Citation:
PMID:  12491747     Owner:  NLM     Status:  MEDLINE    
Hybrid systems are constructs of different molecular entities, natural or unnatural, to generate functional molecules in which the characteristics of various components are modulated, amplified or give rise to entirely new properties. These hybrids can be designed from carefully selected components either through domain integration of key structural/functional features or via straightforward covalent linkages. Some of the recently reported hybrid systems based on steroid, carbohydrate, C60-fullerene platforms, amongst others, mainly crafted with the object of enhancement of the therapeutical spectrum, will be discussed.
Goverdhan Mehta; Vishwakarma Singh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Chemical Society reviews     Volume:  31     ISSN:  0306-0012     ISO Abbreviation:  Chem Soc Rev     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-12-20     Completed Date:  2003-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0335405     Medline TA:  Chem Soc Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  324-34     Citation Subset:  IM    
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India.
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MeSH Terms
Biological Factors / chemistry*
Carbohydrates / chemistry
Drug Design*
Fullerenes / chemistry
Pharmaceutical Preparations / chemical synthesis,  chemistry*
Steroids / chemistry
Reg. No./Substance:
0/Biological Factors; 0/Carbohydrates; 0/Fullerenes; 0/Pharmaceutical Preparations; 0/Steroids; 99685-96-8/fullerene C60

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