| Hybrid small-caliber vascular prosthesis for coronary artery bypass grafting: a preliminary study of plasmin-treated fibrin-coated vascular prosthesis. | |
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MedLine Citation:
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PMID: 16340357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The potential use of plasmin-treated fibrin-coated vascular prosthesis (PF-V) for coronary artery bypass grafting (CABG) in animal models was investigated. PF-V grafts, 3 mm in internal diameter, were studied on 5 sheep in off-pump CABG model and on 18 rabbits in abdominal aortic bypass grafting (AABG) model. Patency, blood flow, angiography, Indium-111 platelet scintigraphy, and histology of the graft were evaluated. In the sheep CABG model, the PF-V grafts were patent for a range of 12 to 22 days without postoperative antiplatelet therapy. Graft flows ranged 58 to 90 ml/min until the day before graft occlusion by thrombus. In rabbit AABG model, the fibrin coating of the PF-V grafts was completely absorbed and replaced with neofibrin net between 7 and 14 days after implantation. Platelet depositions on the graft between 7 and 14 days after implantation were significantly higher than those at other periods (p < 0.05). The small-caliber PF-V graft in sheep CABG model had a good blood flow with high antithrombogenicity in acute phase, but occluded over 2 to 3 weeks without antiplatelet agents after implantation. The current problem of the PF-V graft was a thrombus formation at the time of the degradation of fibrin coating. Further improvements are needed. |
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Authors:
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Tomomi Hasegawa; Kenji Okada; Yoshihito Takano; Yoshiaki Hiraishi; Yoshihiro Yoshida; Yutaka Okita |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 51 ISSN: 1058-2916 ISO Abbreviation: ASAIO J. Publication Date: 2005 Nov-Dec |
Date Detail:
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Created Date: 2005-12-12 Completed Date: 2006-03-02 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 725-9 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular, Thoracic, and Pediatric Surgery, Department of Cardio-Pulmonary and Vascular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Abdominal / surgery Biocompatible Materials Blood Vessel Prosthesis* / adverse effects Coronary Artery Bypass / adverse effects, methods* Fibrin Fibrinolysin Humans Materials Testing Prosthesis Design Rabbits Sheep Surface Properties Thrombosis / etiology, pathology |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 9001-31-4/Fibrin; EC 3.4.21.7/Fibrinolysin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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