| Hybrid liposomes inhibit the growth of cholangiocarcinoma by induction of cell cycle arrest in G1 phase. | |
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MedLine Citation:
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PMID: 20494578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Specific accumulation and cell cycle arrest were observed in human cholangiocarcinoma cells by hybrid liposomes composed of 90 mol% L-alpha-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(21)dodecyl ether (C(12)(EO)(21)) without affecting normal cholangiocytes. |
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Authors:
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Tomomi Towata; Yuji Komizu; Ryusho Kariya; Shinya Suzu; Yoko Matsumoto; Naoya Kobayashi; Chaisiri Wongkham; Sopit Wongkham; Ryuichi Ueoka; Seiji Okada |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-27 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 20 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-04 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 3680-2 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Division of Applied Life Science, Graduate School of Engineering, Sojo University, Ikeda, Kumamoto, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bile Ducts, Intrahepatic
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cytology,
drug effects Cell Cycle / drug effects* Cell Proliferation / drug effects Cholangiocarcinoma / drug therapy*, pathology Dimyristoylphosphatidylcholine G1 Phase / drug effects* Humans Liposomes / chemistry, pharmacology Polyethylene Glycols Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Liposomes; 0/Polyethylene Glycols; 13699-48-4/Dimyristoylphosphatidylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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