Document Detail

Hybrid dysgenesis in Drosophila melanogaster: the biology of female and male sterility.
MedLine Citation:
PMID:  115745     Owner:  NLM     Status:  MEDLINE    
High levels of female and male sterility were observed among the hybrids from one of the two reciprocal crosses between a wild strain of D. melanogaster known as pi2 and laboratory strains. The sterility, which is part of a common syndrome called hybrid dysgenesis, was found to be associated with the rudimentary condition of one or both of the ovaries or testes. All other tissues, including those of the reproductive system were normal, as were longevity and mating behavior. The morphological details of the sterility closely mimic the agametic condition occurring when germ cells are destroyed by irradiation or by the maternal-effect mutation, grandchildless. We suggest that sterility in hybrid dysgenesis is also caused by failure in the early development of germ cells. There is a thermo-sensitive period beginning at approximately the time of initiation of mitosis among primordial germ cells a few hours before the egg hatches and ending during the early larval stages. Our results suggest that hybrid dysgenesis, which also includes male recombination, mutation and other traits, may be limited to the germ line, and that each of the primordial germ cells develops, or fails to develop, independently of the others. This hypothesis is consistent with the observed frequencies of unilateral and bilateral sterility, with the shape of the thermosensitivity curves and with the fact that males are less often sterile than females. The features of this intraspecific hybrid sterility are found to resemble those seen in some interspecific Drosophila hybrids, especially those from the cross D. melanogaster X D. simulans.
W R Engels; C R Preston
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genetics     Volume:  92     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  1979 May 
Date Detail:
Created Date:  1980-01-19     Completed Date:  1980-01-19     Revised Date:  2010-09-01    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  161-74     Citation Subset:  IM    
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MeSH Terms
Crosses, Genetic
Drosophila melanogaster / genetics*
Hybridization, Genetic*
Infertility / genetics*
Recombination, Genetic
Sex Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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