| Hybrid dendritic-linear polyester-ethers for in situ photopolymerization. | |
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MedLine Citation:
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PMID: 11996569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Novel first through fourth generation hybrid dendritic-linear copolymers, composed entirely of building blocks known to be biocompatible or degradable to natural metabolites in vivo, are described. Specifically, these copolymers are composed of poly(ethylene glycol), glycerol, and succinic acid and are synthesized using a divergent approach in high yield. A photo-cross-linkable derivative of this copolymer successfully seals 4.1 mm corneal lacerations. The mechanism of tissue repair is likely one of physical entrapment where an interpenetrating network (IPN) is formed between the cross-linked copolymer and the tissue. |
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Authors:
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Michael A Carnahan; Crystan Middleton; Jitek Kim; Terry Kim; Mark W Grinstaff |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: 124 ISSN: 0002-7863 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-08 Completed Date: 2002-07-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: United States |
Other Details:
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Languages: eng Pagination: 5291-3 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Duke University and Duke University Medical Center, Durham, North Carolina 27708, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Eye Injuries
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drug therapy Glycerol / chemical synthesis*, chemistry, pharmacology Humans Photochemistry Polyethylene Glycols / chemical synthesis*, chemistry, pharmacology Polymers / chemical synthesis*, chemistry, pharmacology Succinic Acids / chemical synthesis*, chemistry, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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R0I-EY 13881/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Polyethylene Glycols; 0/Polymers; 0/Succinic Acids; 25618-55-7/polyglycerol; 56-81-5/Glycerol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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