Document Detail


Hybrid Nanomaterials that Mimic the Food Effect: Controlling Enzymatic Digestion for Enhanced Oral Drug Absorption.
MedLine Citation:
PMID:  22505292     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Easily digested: SiO(2) -lipid hybrid microparticles with specific nanostructured interiors were generated from submicrometer-sized emulsion templates based on mesoporous and non-porous silica nanoparticles. These functional lipid-based microparticles can be used to mimic the pharmaceutical food effect and enhance drug absorption by controlling the enzymatic digestion of lipid colloids (see scheme; ○ oil solution, ▵ lipid-nanoparticle hybrid, □ lipid encapsulated in hybrid).
Authors:
Angel Tan; Amanda Martin; Tri-Hung Nguyen; Ben J Boyd; Clive A Prestidge
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-13
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  -     ISSN:  1521-3773     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Ian Wark Research Institute, University of South Australia, Mawson Lakes, South Australia 5095 (Australia) http://unisa.edu.au/iwri/staffpages/cliveprestidge.asp.
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