| Hybrid SPECT/CT for Attenuation Correction of Stress Myocardial Perfusion Imaging. | |
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MedLine Citation:
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PMID: 21467849 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: : This study aimed to determine whether attenuation correction using the Hybrid SPECT/CT reduced attenuation artifacts. METHODS AND RESULTS: : Ninety-nine patients (55 men and 44 women) underwent coronary angiography and electrocardiography gated stress/rest myocardial perfusion imaging using Tc-99m sestamibi (MIBI) with CT-attenuation correction (CT-AC) for stress scans. Visual semi-quantitative analysis of the CT-AC and noncorrected perfusion images was performed. In this study, there was 39.3% moderate or severe misregistration. The overall specificity, sensitivity, and accuracy for noncorrected versus CT-AC were 62.9% versus 79.0% (P = 0.041), 94.6% versus 91.9% (P = NS), and 74.7% versus 83.8% (P = 0.035), respectively. CT-AC increased specificity in the right coronary artery region, from 77.9% to 98.7% (P = 0.000), accompanied by a decrease in specificity in the left anterior descending region, from 94.1% to 82.4% (P = 0.008). CT-AC significantly reduced defect scores in the inferior wall. This was more obvious in men than in women (P = 0.027). In the anterior wall, although a tendency for defect scores to increase with CT-AC was observed only in men, no significant difference was found between the gender (P = 0.049). CONCLUSION: : Attenuation correction using Hybrid SPECT/CT improved specificity in the right coronary artery, but decreased specificity in the left anterior descending. This technique is likely to be more useful in men than in women. |
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Authors:
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Rui Huang; Fanglan Li; Zhen Zhao; Bin Liu; Xiaohong Ou; Rong Tian; Lin Li |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 36 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 344-9 Citation Subset: IM |
Affiliation:
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From the Department of Nuclear Medicine, National Key Discipline of Medical Imaging and Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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