| Hybrid (18)F-FDG PET-MRI of the hand in rheumatoid arthritis: initial results. | |
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MedLine Citation:
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PMID: 21590292 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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18F-fluorodeoxyglucose PET (18F-FDG PET) is highly sensitive to inflammatory changes within the synovial tissue in rheumatoid arthritis (RA). However, the highest spatial resolution for soft tissue can be achieved with MRI. Here, we report on the first true hybrid PET-MRI examination of the hand in early RA exploiting the advantages of both modalities. PET-MRI was performed with a prototype of an APD-based magneto-insensitive BrainPET detector (Siemens Healthcare, Erlangen, Germany) operated within a standard 3T MR scanner (MAGNETOM Trio, Siemens). PET images were normalized, random, attenuation and scatter-corrected, iteratively reconstructed and calibrated to yield standardized uptake values (SUV) of 18F-FDG uptake. T1-weighted TSE in coronal as well as sagittal orientation prior to and following Gadolinium administration were acquired. Increased 18F-FDG uptake was present in synovitis and tenovaginitis as identified on contrast-enhanced MRI. The tracer distribution was surrounding the metacarpophalangeal joints II and III. Maximum SUV of 3.1 was noted. In RA, true hybrid 18F-FDG PET-MRI of the hand is technically feasible and bears the potential to directly visualize inflammation. |
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Authors:
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Falk Miese; Axel Scherer; Benedikt Ostendorf; Alexander Heinzel; Rotem S Lanzman; Patric Kröpil; Dirk Blondin; Hubertus Hautzel; Hans-Jörg Wittsack; Matthias Schneider; Gerald Antoch; Hans Herzog; N Jon Shah |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-18 |
Journal Detail:
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Title: Clinical rheumatology Volume: - ISSN: 1434-9949 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211469 Medline TA: Clin Rheumatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Neuroscience and Medicine-4, Forschungszentrum Jülich GmbH, 52425, Jülich, Germany, dr.miese@gmx.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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