Document Detail


Hyaluronidase in human somatic tissues and urine: polymorphism and the activity in diseases.
MedLine Citation:
PMID:  7653157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The polymorphism of hyaluronidase (EC 3.2.1.35) (Hyase) was studied on a hyaluronan-polyacrylamide gel. Liver, placenta, ovary and breast tissue were found to have 7 active isoforms while leukocytes and platelets 5 and fibroblasts displayed no hyaluronidase activity. In serum, synovial fluid and urine soluble the most acidic forms are present. Desialylation showed that most of the hyaluronidase isoforms differ in the content of sialic acid. In patients with rheumatoid arthritis, hyaluronidase activity in the synovial fluid varied from not detectable to very high. A partial deficiency was demonstrated in sera from some patients with dysostosis multiplex without mucopolysacchariduria. In I-cell disease, hyaluronidase activity in serum was as that in controls.
Authors:
B Fiszer-Szafarz; P Vannier; A Lityńska; L Zou; B Czartoryska; A Tylki-Szymańska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta biochimica Polonica     Volume:  42     ISSN:  0001-527X     ISO Abbreviation:  Acta Biochim. Pol.     Publication Date:  1995  
Date Detail:
Created Date:  1995-09-28     Completed Date:  1995-09-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  14520300R     Medline TA:  Acta Biochim Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  31-3     Citation Subset:  IM    
Affiliation:
Institut Curie-Biologie, Centre Universitaire, Orsay, France.
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Rheumatoid / enzymology*
Child
Female
Humans
Hyaluronoglucosaminidase / chemistry,  metabolism*,  urine
Isoenzymes / metabolism*
Male
Mucopolysaccharidoses / enzymology*
Synovial Fluid / metabolism
Tissue Distribution
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 3.2.1.35/Hyaluronoglucosaminidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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