Document Detail

Hyaluronidase in the correction of hyaluronic acid-based fillers: a review and a recommendation for use.
MedLine Citation:
PMID:  19958438     Owner:  NLM     Status:  In-Process    
BACKGROUND: Hyaluronic acid (HA) preparations are the most commonly used injectable fillers in esthetic medicine. In contrast to other injectable fillers with hyaluronidase, there is a tool available to reduce unwanted depots of this filler. AIMS: The aim of this paper is to give an overview on the present literature and in addition to give some recommendations for use based on the experience of the authors. METHODS: The overview is based on a literature search. RESULTS: There is some evidence from two smaller clinical trials that hyaluronidase will effectively decrease injected depots of HA. It has further been shown from case series and case reports that this reduction is clinically relevant. There is less evidence that hyaluronidase is also helpful in adverse reactions to HA-based fillers. CONCLUSIONS: The reports suggest that the treatment is safe. However, adverse reactions to hyaluronidase such as allergic reactions have been reported. Patient should be informed about that before treatment.
Berthold Rzany; Petra Becker-Wegerich; Frank Bachmann; Ricardo Erdmann; Uwe Wollina
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cosmetic dermatology     Volume:  8     ISSN:  1473-2165     ISO Abbreviation:  J Cosmet Dermatol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130964     Medline TA:  J Cosmet Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  317-23     Citation Subset:  IM    
Division of Evidence-based Medicine, Klinik für Dermatologie, Charité Universitätsmedizin, Berlin, Deutschland.
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