Document Detail

Hyaluronidase inhibitors from "Cimicifugae Rhizoma" (a mixture of the rhizomes of Cimicifuga dahurica and C. heracleifolia).
MedLine Citation:
PMID:  20192237     Owner:  NLM     Status:  MEDLINE    
From the 80% acetone extract of "Cimicifugae Rhizoma" (a mixture of Cimicifuga dahurica and C. heracleifolia used medicinally), seven new fukiic acid derivatives (1-7) and a new phenylethanoid derivative (8) were isolated along with eight known compounds (9-16). Fukinolic acid (9) and cimicifugic acids A-J (10-16, 5-7) showed stronger hyaluronidase inhibitory activities than the positive control, rosmarinic acid.
Atsufumi Iwanaga; Genjiro Kusano; Tsutomu Warashina; Toshio Miyase
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of natural products     Volume:  73     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  573-8     Citation Subset:  IM    
School of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Suruga-ku, Shizuoka 422-8526, Japan.
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MeSH Terms
Caffeic Acids / chemistry,  isolation & purification*,  pharmacology*
Cimicifuga / chemistry*
Cinnamates / chemistry
Depsides / chemistry
Hyaluronoglucosaminidase / antagonists & inhibitors*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Phenylacetates / chemistry,  isolation & purification*,  pharmacology*
Phenylpropionates / chemistry,  isolation & purification*,  pharmacology*
Plants, Medicinal / chemistry*
Rhizome / chemistry
Succinates / chemistry,  isolation & purification*,  pharmacology*
Reg. No./Substance:
0/Caffeic Acids; 0/Cinnamates; 0/Depsides; 0/Phenylacetates; 0/Phenylpropionates; 0/Succinates; 0/cimicifugic acid; 35388-56-8/fukiic acid; 50982-40-6/fukinolic acid; 537-15-5/rosmarinic acid; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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