Document Detail

Hyaluronidase: Here we go again.
MedLine Citation:
PMID:  19577408     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To summarize the benefits and lateral effects of hyaluronidase (H) use in ophthalmologic anaesthesia and to address its unavailability in current practice in France. DATA SOURCES: The Medline data bank and the Cochrane database were consulted. The keywords employed separately or in combination were: H, regional anaesthesia, ophthalmologic surgery, local aneasthetics myotoxicity, diplopia. STUDY SELECTION: Original articles since 1949 were selected. We also selected isolated clinical cases according to their relevance compared with the existing literature. DATA SYNTHESIS: H is a "spreading factor" of animal origin used as an adjuvant in ophthalmic anaesthesia for more than half a century. It allows a moderate better block quality with a slightly quicker onset. It also limits the acute intraocular pressure increase secondary to periocular injection and seems to have a protective effect against local anaesthetics myotoxicity resulting in postoperative strabismus. However, during these last 50 years, numerous studies often ended in divergent results. CONCLUSION: H seems to be a useful adjuvant in ophthalmologic anaesthesia in spite of his current unavailability in France. Recombinant H could be the solution in the near future.
B Etesse; L Beaudroit; M Deleuze; E Nouvellon; J Ripart
Publication Detail:
Type:  English Abstract; Journal Article; Multicenter Study; Review     Date:  2009-07-03
Journal Detail:
Title:  Annales françaises d'anesthèsie et de rèanimation     Volume:  28     ISSN:  1769-6623     ISO Abbreviation:  Ann Fr Anesth Reanim     Publication Date:    2009 Jul-Aug
Date Detail:
Created Date:  2009-08-03     Completed Date:  2009-10-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8213275     Medline TA:  Ann Fr Anesth Reanim     Country:  France    
Other Details:
Languages:  fre     Pagination:  658-65     Citation Subset:  IM    
Pôle Anesthésie-Douleur-urgences-Réanimation, Groupe Hospitalo-Universitaire Carémeau, 30029 Nîmes cedex 09, France.
Vernacular Title:
Hyaluronidase: plaidoyer pour un retour.
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MeSH Terms
Adjuvants, Anesthesia*
Anesthesia, Conduction*
Diplopia / surgery
Hyaluronoglucosaminidase / administration & dosage,  therapeutic use*
Intraocular Pressure / drug effects
Ophthalmologic Surgical Procedures*
Ophthalmoplegia / chemically induced,  prevention & control
Postoperative Complications / prevention & control
Protective Agents / therapeutic use
Strabismus / etiology,  prevention & control
Reg. No./Substance:
0/Adjuvants, Anesthesia; 0/Protective Agents; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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