Document Detail

Hyaluronic acid and proteoglycan accumulation in the cumulus oophorus matrix.
MedLine Citation:
PMID:  11322326     Owner:  NLM     Status:  MEDLINE    
A factor produced by the oocytes induces in vitro FSH-treated cumulus and mural granulosa cells to synthesize hyaluronic acid. In the present study we examined hyaluronic acid synthesis by the two cell populations in vivo. After injection of hCG into PMSG-primed immature mice, cumulus and mural granulosa cells adjacent to the antrum synthesized a large amount of such glycosaminoglycan, while the outermost layers layers of mural granulosa cells did not. The results suggest that in vivo differences in hyaluronic acid synthesis between follicle cell subpopulations depend on a diffusion gradient of the oocyte factor. We also identified a proteoglycan species synthesized by cumulus cells which may contribute to hyaluronic acid organization in the intercellular spaces.
A Salustri; A Camaioni; E Tirone; C D'Alessandris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia     Volume:  100 Suppl 1     ISSN:  1122-6714     ISO Abbreviation:  Ital J Anat Embryol     Publication Date:  1995  
Date Detail:
Created Date:  2001-04-26     Completed Date:  2001-06-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9612303     Medline TA:  Ital J Anat Embryol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  479-84     Citation Subset:  IM    
Department of Public Health and Cell Biology, Faculty of Medicine, University of Rome Tor Vergata, Italy.
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MeSH Terms
Cells, Cultured / cytology,  drug effects,  metabolism
Chorionic Gonadotropin / pharmacology
Estrus / drug effects,  physiology
Extracellular Matrix / drug effects,  metabolism*
Granulosa Cells / cytology,  drug effects,  metabolism*
Hyaluronic Acid / biosynthesis*
Ovulation / drug effects,  physiology
Proteoglycans / biosynthesis*
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Proteoglycans; 9004-61-9/Hyaluronic Acid

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