Document Detail

Hyaluronic acid-based hydrogel induces neovascularization and improves cardiac function in a rat model of myocardial infarction.
MedLine Citation:
PMID:  23851989     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The use of stem cells in cardiac regeneration is still limited due to low cellular integration and engraftment rates. Consequently, there has been a spurt in research on developing alternative regenerative therapies. Hyaluronic acid (HA) is a major component of the extracellular matrix that is non-immunogenic, and has been implicated in various wound-healing functions such as angiogenesis and inflammation modulation, making it an ideal candidate for regenerative biomaterials. In this study, we examine the potential of acellular hyaluronic acid-based hydrogel in improving cardiac function post-myocardial infarction in a rat model.
METHODS: Hyaluronic acid-based hydrogel was injected into the peri-infarct region post-myocardial infarction induction in Lewis rats. Cardiac function in control (n = 10) and gel-injected groups (n = 10) was evaluated up to 4 weeks post-myocardial infarction. Evaluation of cardiac function was conducted using transthoracic echocardiography. Histological analysis of scar area was evaluated via haematoxylin and eosin (H & E), and Sirius red staining. Neovascularization was detected using vascular endothelial growth factor (VEGF) staining.
RESULTS: Evaluation of cardiac function using transthoracic echocardiography revealed a 18.2% (P < 0.01) increase in ejection fraction in gel-injected groups when compared with the control group, almost returning the ejection fraction to baseline levels (preop). Histological analysis of scar area by haematoxylin and eosin (H&E), and Sirius red staining demonstrated decreased scarring, and a 22.6% (P < 0.01) decrease in collagen deposition in the gel-injected group compared with the control group. VEGF staining indicated a significant increase in novel vasculature formation in hydrogel-injected groups when compared with control.
CONCLUSIONS: Due to its regenerative potential, hyaluronic acid-based hydrogel provides a promising novel therapy to be used alone, or as a scaffold delivering a variety of drugs or cells to combat heart disease in a multifaceted approach.
Sherif Abdalla; Georges Makhoul; Minh Duong; Ray C J Chiu; Renzo Cecere
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-07-12
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  17     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-10-23     Completed Date:  2014-06-17     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  767-72     Citation Subset:  IM    
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MeSH Terms
Disease Models, Animal
Hyaluronic Acid / administration & dosage*
Injections, Intralesional
Myocardial Infarction / metabolism,  physiopathology,  therapy*,  ultrasonography
Myocardium / metabolism,  pathology
Neovascularization, Physiologic*
Rats, Inbred Lew
Recovery of Function
Stroke Volume
Time Factors
Vascular Endothelial Growth Factor A / metabolism
Ventricular Function, Left
Reg. No./Substance:
0/Hydrogels; 0/Vascular Endothelial Growth Factor A; 0/vascular endothelial growth factor A, rat; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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