Document Detail

Hyaluronic Acid/Poly(β-Amino Ester) Polymer Nanogels for Cancer-Cell-Specific NIR Fluorescence Switch.
MedLine Citation:
PMID:  22753358     Owner:  NLM     Status:  Publisher    
Cancer-cell-specific pH-activatable polymer nanogels consisting of CD44-receptor-targeting hyaluronic acid (HA), pH-sensitive poly(β-amino ester) (PBAE), and near-infrared (NIR) fluorescent indocyanine green (ICG) were synthesized and used to detect cancer cells. The HA/PBAE/ICG-polymer-nanogel-based NIR probe was nonfluorescent outside of tumor cells. After internalization by CD44-receptor-mediated endocytosis, the probe accumulated in the late endosomes or lysosomes where the acidic pH solubilized the PBAE and caused instant disassembly of the polymer nanogel. During endosomal maturation, the encapsulated ICG was released from its quenched state, inducing strong NIR fluorescence recovery. The nanogels generate a highly tumor-specific NIR signal with a reduced background signal.
Hye Sun Park; Jung Eun Lee; Mi Young Cho; Ji Hyeon Hong; Sang Hee Cho; Yong Taik Lim
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-2
Journal Detail:
Title:  Macromolecular rapid communications     Volume:  -     ISSN:  1521-3927     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9888239     Medline TA:  Macromol Rapid Commun     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Graduate School and Department of Analytical, Science and Technology, Chungnam National University, Yuseong, Daejeon 305-764, Republic of Korea.
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