Document Detail

Hyaluronan induces migration of multidrug-resistant lymphoma cell lines in vitro through Tiam1 activation by a PI3K-dependent mechanism.
MedLine Citation:
PMID:  20299090     Owner:  NLM     Status:  MEDLINE    
Hyaluronan (HA) modulates multidrug resistance (MDR) as well as cell migration. Tiam1 is involved in cytoskeleton reorganization during tumor invasion. In this report we show the relationship among HA, Tiam1, migration and MDR in murine lymphoma cell lines. We observed that MDR cells presented higher migratory capacity towards HA in vitro as well as higher constitutive active Tiam1 expression than the sensitive cell line. Besides, HA treatment induced migration towards HA of MDR cell lines through Tiam1 activation by a PI3K-dependent mechanism, showing that disruption of HA signaling would be useful in treatment of MDR hematological malignancies.
Rosalía I Cordo-Russo; Laura D Alaniz; Natalia Saccodossi; Silvina Lompardía; Guillermo Blanco; Elida Alvarez; Mariana G García; Silvia E Hajos
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-17
Journal Detail:
Title:  Leukemia research     Volume:  34     ISSN:  1873-5835     ISO Abbreviation:  Leuk. Res.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2010-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1525-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Department of Immunology, School of Pharmacy and Biochemistry, University of Buenos Aires, IDEHU-CONICET, Buenos Aires, Argentina.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
1-Phosphatidylinositol 3-Kinase / metabolism*
Cell Line, Tumor
Cell Movement / drug effects*
Drug Resistance, Multiple*
Guanine Nucleotide Exchange Factors / metabolism*
Hyaluronic Acid / pharmacology*
Lymphoma / drug therapy*,  pathology
Signal Transduction
Reg. No./Substance:
0/Guanine Nucleotide Exchange Factors; 0/TIAM1 protein, human; 9004-61-9/Hyaluronic Acid; EC 3-Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Use of a specific MMP-inhibitor (galardin) for preservation of hybrid layer.
Next Document:  Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23);MLL-MLLT...