Document Detail


Hyaluronan in human acute and chronic dermal wounds.
MedLine Citation:
PMID:  16808803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is growing interest in the relationship of hyaluronan and inflammation in a number of physiologic processes including wound healing. The objective of this study was to make a quantitative comparison of inflammation and hyaluronan expression in human normal healing open wounds and in pressure ulcers. Using an open dermal wound model, myeloperoxidase activity was found to peak at day 3. Hyaluronan levels showed a bimodal distribution with transient peaks occurring on days 1 and 7. Mean levels of myeloperoxidase activity in pressure ulcers were significantly higher than at any time in the acute wounds, whereas hyaluronan levels were significantly lower than at any time in the acute wounds. Levels of hyaluronidase activity increased slightly in the postwound period. Hyaluronidase activity in pressure ulcers was significantly elevated compared with the acute wounds. These results suggest a role for increased enzymatic degradation of hyaluronan as a function of inflammation during wound repair. This is the first reported quantitative examination of hyaluronan expression in human acute dermal wounds and in chronic pressure ulcers.
Authors:
Tracey A Dechert; Ashley E Ducale; Susan I Ward; Dorne R Yager
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society     Volume:  14     ISSN:  1067-1927     ISO Abbreviation:  Wound Repair Regen     Publication Date:    2006 May-Jun
Date Detail:
Created Date:  2006-06-30     Completed Date:  2006-12-19     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9310939     Medline TA:  Wound Repair Regen     Country:  United States    
Other Details:
Languages:  eng     Pagination:  252-8     Citation Subset:  IM    
Affiliation:
Department of Surgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA.
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MeSH Terms
Descriptor/Qualifier:
Chronic Disease
Enzyme-Linked Immunosorbent Assay
Humans
Hyaluronic Acid / chemistry,  metabolism*
Hyaluronoglucosaminidase / metabolism
Inflammation
Molecular Weight
Peroxidase / metabolism
Pressure Ulcer / metabolism
Skin / injuries*,  metabolism,  pathology
Wound Healing*
Grant Support
ID/Acronym/Agency:
GM20298/GM/NIGMS NIH HHS; GM58530/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
9004-61-9/Hyaluronic Acid; EC 1.11.1.7/Peroxidase; EC 3.2.1.35/Hyaluronoglucosaminidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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