Document Detail

Hyaluronan Matrices in Pathobiological Processes.
MedLine Citation:
PMID:  21362136     Owner:  NLM     Status:  Publisher    
Hyaluronan matrices are ubiquitous in normal and pathological biological processes. This remarkable diversity is related to its unique mechanism of synthesis by the hyaluronan synthases. These enzymes are normally activated in the plasma membrane and utilize cytosolic substrates directly to form this large polyanionic glycosaminoglycan, which is extruded directly into the extracellular space. The extracellular matrices that are formed interact with cell surface receptors, notably CD44, that often dictate biological processes as described in the accompanying minireviews of this series. This article focuses on the recent studies that have discovered that many cell stress responses initiate synthesis of a monocyte-adhesive hyaluronan extracellular matrix that forms a central focus for subsequent inflammatory processes that are modulated by the dialogue between the matrix and the inflammatory cells. The mechanisms involve active hyaluronan synthases at the cell membrane when cell stresses occur in physiological levels of glucose. However, dividing cells in hyperglycemic levels of glucose initiate synthesis of hyaluronan in intracellular compartments, which induces endoplasmic reticulum stress and autophagy, processes that likely contribute greatly to diabetic pathologies.
Aimin Wang; Carol de la Motte; Mark Lauer; Vincent Hascall
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-1
Journal Detail:
Title:  The FEBS journal     Volume:  -     ISSN:  1742-4658     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101229646     Medline TA:  FEBS J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Journal compilation © 2011 Federation of European Biochemical Societies.
Departments of Biomedical Engineering Pathobiology, The Cleveland Clinic, Cleveland, Ohio 44195.
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