| Hyalinizing clear cell carcinoma: report of eight cases and a review of literature. | |
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MedLine Citation:
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PMID: 20596970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyalinizing clear cell carcinoma (HCCC) is an extremely rare neoplasm with a female predominance, composed of nests of monomorphic clear cells within a hyaline stroma. This tumor often follows an indolent course and treatment includes wide surgical excision with or without adjuvant radiotherapy. We report eight cases of HCCC identified at two academic institutions in six women and two men, ranging in age from 25 to 86 years. Histologically, all cases demonstrated cords, trabeculae, and nests of monomorphic clear cells as well as cells with eosinophilic granular cytoplasm. Mild cellular atypia was occasionally seen and mitoses were very rare. Seven cases demonstrated a hyalinized stroma, and one case, a myxoid stroma. Immunohistochemically, the tumor cells were positive for epithelial markers and negative for desmin and actin. Seven cases were negative for S-100. Cells were also positive for periodic acid-Schiff and negative for mucin. The important clinicopathologic features and the differential diagnoses of HCCC, as well as a review of the literature are discussed. |
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Authors:
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E D O'Sullivan-Mejia; H D Massey; W C Faquin; C N Powers |
Publication Detail:
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Type: Case Reports; Journal Article; Multicenter Study; Review Date: 2009-07-05 |
Journal Detail:
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Title: Head and neck pathology Volume: 3 ISSN: 1936-0568 ISO Abbreviation: Head Neck Pathol Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2010-07-02 Completed Date: 2010-10-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101304010 Medline TA: Head Neck Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 179-85 Citation Subset: IM |
Affiliation:
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Virginia Commonwealth University Health System, Richmond, VA, USA. eo'sullivan-mejia@mcvh-vcu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma, Clear Cell
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pathology* Adult Aged Aged, 80 and over Female Humans Hyalin / metabolism Immunohistochemistry Male Middle Aged Salivary Gland Neoplasms / pathology* |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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