Document Detail

Hyalinizing clear cell carcinoma: report of eight cases and a review of literature.
MedLine Citation:
PMID:  20596970     Owner:  NLM     Status:  MEDLINE    
Hyalinizing clear cell carcinoma (HCCC) is an extremely rare neoplasm with a female predominance, composed of nests of monomorphic clear cells within a hyaline stroma. This tumor often follows an indolent course and treatment includes wide surgical excision with or without adjuvant radiotherapy. We report eight cases of HCCC identified at two academic institutions in six women and two men, ranging in age from 25 to 86 years. Histologically, all cases demonstrated cords, trabeculae, and nests of monomorphic clear cells as well as cells with eosinophilic granular cytoplasm. Mild cellular atypia was occasionally seen and mitoses were very rare. Seven cases demonstrated a hyalinized stroma, and one case, a myxoid stroma. Immunohistochemically, the tumor cells were positive for epithelial markers and negative for desmin and actin. Seven cases were negative for S-100. Cells were also positive for periodic acid-Schiff and negative for mucin. The important clinicopathologic features and the differential diagnoses of HCCC, as well as a review of the literature are discussed.
E D O'Sullivan-Mejia; H D Massey; W C Faquin; C N Powers
Publication Detail:
Type:  Case Reports; Journal Article; Multicenter Study; Review     Date:  2009-07-05
Journal Detail:
Title:  Head and neck pathology     Volume:  3     ISSN:  1936-0568     ISO Abbreviation:  Head Neck Pathol     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2010-07-02     Completed Date:  2010-10-05     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101304010     Medline TA:  Head Neck Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  179-85     Citation Subset:  IM    
Virginia Commonwealth University Health System, Richmond, VA, USA. eo'
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MeSH Terms
Adenocarcinoma, Clear Cell / pathology*
Aged, 80 and over
Hyalin / metabolism
Middle Aged
Salivary Gland Neoplasms / pathology*

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