Document Detail


Hurst analysis in the study of ion channel kinetics.
MedLine Citation:
PMID:  8520548     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ion channels are protein molecules which can assume distinct open and closed conformational states. The transitions between these states can be controlled by the electrical field, ions and/or drugs. Records of unitary current events show that short open-time intervals are frequently adjacent to much longer closed-time intervals, and vice-versa, suggesting that the kinetic process has memory, i.e., the intervals are correlated in time. Here the rescaled range analysis (R/S Hurst analysis) is proposed as a method to test for correlation. Simulations were performed with a two-state Markovian model, which has no memory. The calculated Hurst coefficients (H) presented a mean +/- SD value of 0.493 +/- 0.025 (N = 100). For the Ca(2+)-activated K+ channels of Leydig cells, H was equal to 0.75, statistically different (1% level) from that calculated for the memoryless process. Randomly shuffling the experimental data resulted in an H = 0.55, not significantly different (1% level) from that found for the two-state Markovian model. For a linear three-state Markovian model, H was equal to 0.548 +/- 0.017 (N = 15), again not significantly different (1% level) from that of the memoryless process. Although the three-state Markovian model adequately describes the open- and closed-time distributions, it does not account for the correlation found in this Ca(2+)-activated K+ channel. Our results illustrate the efficacy of the R/S analysis in determining whether successive opening and closing events are correlated in time and can be of help in deciding which model should be used to describe the kinetics of ion channels.
Authors:
R A Nogueira; W A Varanda; L S Liebovitch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  28     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1996-01-24     Completed Date:  1996-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  491-6     Citation Subset:  IM    
Affiliation:
Departamento de Biofísica e Radiobiologia, Universidade Federal de Pernambuco, Recife, PE, Brasil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Ion Channel Gating
Ion Channels / physiology*
Kinetics
Markov Chains
Mice
Models, Biological
Chemical
Reg. No./Substance:
0/Ion Channels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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