Document Detail


Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation.
MedLine Citation:
PMID:  11403956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Huperzine A (HupA) and donepezil, two novel selective acetylcholinesterase inhibitors available for Alzheimer's disease, were tested for their ability to alleviate injury from oxygen-glucose deprivation (OGD) in the rat pheochromocytoma line PC12 cells. OGD for 30 min triggered death in more than 50% of cells, along with major changes in morphology and biochemistry including elevated levels of lipid peroxide, superoxide disamutase activity and lactate. Cells pretreated for 2 h with HupA or donepezil showed improved survival and reduced biochemical and morphologic signs of toxicity (statistically significant over the range from 10 microM down to 1.0 and 0.1 microM, respectively). Our results indicated that HupA and donepezil protected PC12 cells against OGD-induced toxicity, most likely by alleviating disturbances of oxidative and energy metabolism.
Authors:
J Zhou; Y Fu; X C Tang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  306     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-13     Completed Date:  2001-08-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  53-6     Citation Subset:  IM    
Affiliation:
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Tai-yuan Road, 200031, Shanghai, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / drug therapy*,  metabolism,  physiopathology
Animals
Cell Size / drug effects,  physiology
Cell Survival / drug effects,  physiology
Cholinesterase Inhibitors / pharmacology*
Dose-Response Relationship, Drug
Glucose / deficiency*
Hypoxia-Ischemia, Brain / drug therapy*,  metabolism,  physiopathology
Indans / pharmacology*
Lipid Peroxidation / drug effects,  physiology
Malondialdehyde / metabolism
Neuroprotective Agents / pharmacology*
Oxidative Stress / drug effects,  physiology
PC12 Cells / cytology,  drug effects,  metabolism
Piperidines / pharmacology*
Rats
Sesquiterpenes / pharmacology*
Superoxide Dismutase / drug effects,  metabolism
Tetrazolium Salts / pharmacokinetics
Thiazoles / pharmacokinetics
Chemical
Reg. No./Substance:
0/Cholinesterase Inhibitors; 0/Indans; 0/Neuroprotective Agents; 0/Piperidines; 0/Sesquiterpenes; 0/Tetrazolium Salts; 0/Thiazoles; 102518-79-6/huperzine A; 120011-70-3/donepezil; 298-93-1/thiazolyl blue; 50-99-7/Glucose; 542-78-9/Malondialdehyde; EC 1.15.1.1/Superoxide Dismutase

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