Document Detail


Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammation.
MedLine Citation:
PMID:  19429337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
ETHNOPHARMACOLOGICAL RELEVANCE: HLXL is a traditional Chinese medicine that has long been used in folk medicine for the treatment of chronic inflammatory diseases. However, the precise immunological mechanisms by which HLXL mediates its anti-inflammatory activity are not fully defined.
AIM OF THE STUDY: To determine the effects of HLXL on antigen-specific immune parameters in adjuvant-induced inflammation model in the Lewis rat.
MATERIALS AND METHODS: Rats were fed daily with either HLXL (2.3g/kg) or vehicle (water) beginning 3 days before subcutaneous injection of heat-killed Mycobacterium tuberculosis H37Ra (Mtb), and then continued for another 6 days. After 9 days of Mtb injection, the draining lymph node cells were tested for T cell proliferative and cytokine responses against mycobacterial heat-shock protein 65 (Bhsp65). Moreover, sera were tested for anti-Bhsp65 antibodies and nitric oxide (NO).
RESULTS: HLXL-treated rats showed reduced T cell proliferative response to Bhsp65 compared to control rats. Furthermore, HLXL suppressed IL-17 response but enhanced IL-10 response without much effect on IFN-gamma. HLXL treatment also reduced the levels of anti-Bhsp65 antibodies but not that of NO.
CONCLUSIONS: HLXL feeding modulated both the cellular and the humoral immune response to Bhsp65 favoring an anti-inflammatory milieu for the suppression of adjuvant-induced inflammation.
Authors:
Rajesh Rajaiah; David Y-W Lee; Zhongze Ma; Arthur Y Fan; Lixing Lao; Harry H S Fong; Brian M Berman; Kamal D Moudgil
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-03-04
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  123     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-08-12     Revised Date:  2011-09-26    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  40-4     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibody Formation
Antigens / immunology*
Cytokines / metabolism
Disease Models, Animal
Inflammation / chemically induced,  immunology,  therapy*
Inflammation Mediators / metabolism
Male
Medicine, Chinese Traditional*
Rats
Rats, Inbred Lew
Grant Support
ID/Acronym/Agency:
P01 AT002605-01A1/AT/NCCAM NIH HHS; P01 AT002605-01A10003/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
0/Antigens; 0/Cytokines; 0/Inflammation Mediators
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