| Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammation. | |
| | |
MedLine Citation:
|
PMID: 19429337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
ETHNOPHARMACOLOGICAL RELEVANCE: HLXL is a traditional Chinese medicine that has long been used in folk medicine for the treatment of chronic inflammatory diseases. However, the precise immunological mechanisms by which HLXL mediates its anti-inflammatory activity are not fully defined. AIM OF THE STUDY: To determine the effects of HLXL on antigen-specific immune parameters in adjuvant-induced inflammation model in the Lewis rat. MATERIALS AND METHODS: Rats were fed daily with either HLXL (2.3g/kg) or vehicle (water) beginning 3 days before subcutaneous injection of heat-killed Mycobacterium tuberculosis H37Ra (Mtb), and then continued for another 6 days. After 9 days of Mtb injection, the draining lymph node cells were tested for T cell proliferative and cytokine responses against mycobacterial heat-shock protein 65 (Bhsp65). Moreover, sera were tested for anti-Bhsp65 antibodies and nitric oxide (NO). RESULTS: HLXL-treated rats showed reduced T cell proliferative response to Bhsp65 compared to control rats. Furthermore, HLXL suppressed IL-17 response but enhanced IL-10 response without much effect on IFN-gamma. HLXL treatment also reduced the levels of anti-Bhsp65 antibodies but not that of NO. CONCLUSIONS: HLXL feeding modulated both the cellular and the humoral immune response to Bhsp65 favoring an anti-inflammatory milieu for the suppression of adjuvant-induced inflammation. |
| | |
Authors:
|
Rajesh Rajaiah; David Y-W Lee; Zhongze Ma; Arthur Y Fan; Lixing Lao; Harry H S Fong; Brian M Berman; Kamal D Moudgil |
Related Documents
:
|
17233587 - Phosphoinositides in phagolysosome and autophagosome biogenesis. 15882357 - The influence of age on immunity to infection with mycobacterium tuberculosis. 17504117 - Th2 cytokines in susceptibility to tuberculosis. 12758197 - Human immunity to m. tuberculosis: t cell subsets and antigen processing. 18220747 - Autoimmunity and apoptosis--therapeutic implications. 12832417 - Forced expression of the h11 heat shock protein can be regulated by dna methylation and... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-03-04 |
Journal Detail:
|
Title: Journal of ethnopharmacology Volume: 123 ISSN: 1872-7573 ISO Abbreviation: J Ethnopharmacol Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-05-11 Completed Date: 2009-08-12 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 40-4 Citation Subset: IM |
Affiliation:
|
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antibody Formation Antigens / immunology* Cytokines / metabolism Disease Models, Animal Inflammation / chemically induced, immunology, therapy* Inflammation Mediators / metabolism Male Medicine, Chinese Traditional* Rats Rats, Inbred Lew |
| Grant Support | |
ID/Acronym/Agency:
|
P01 AT002605-01A1/AT/NCCAM NIH HHS; P01 AT002605-01A10003/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antigens; 0/Cytokines; 0/Inflammation Mediators |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antihypertensive effect of 3,3,5,5-tetramethyl-4-piperidone, a new compound extracted from Marasmius...
Next Document: Ethnopharmacological survey of wild medicinal plants in Showbak, Jordan.