Document Detail


Huntington's disease: a molecular genetic and CT comparison.
MedLine Citation:
PMID:  8708657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Huntington's disease is a progressive neurodegenerative disease in which the molecular abnormality has recently been described. Before the availability of this molecular marker diagnosis depended on clinical findings, supported in some instances by neuroimaging using CT or MRI. The imaging modalities may show atrophy of the heads of caudate nuclei in affected people. An attempt was made to validate these imaging findings using the molecular test as "gold standard." Retrospective analysis of cranial CT in 16 patients with Huntington's disease and 16 age and sex matched controls was performed. There was a highly significant difference in caudate head size (P < 0.00001) between patients with Huntington's disease and control subjects. However, the sensitivity of diagnosis based on radiological examination alone was only 87.5% in this study. Thus the sensitivity of CT is insufficient to justify its routine use in the investigation of suspected Huntington's disease, unless genetic tests are negative and other diagnoses need to be excluded.
Authors:
P Sharma; L Savy; J Britton; R Taylor; A Howick; M Patton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  60     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-09-10     Completed Date:  1996-09-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  206-8     Citation Subset:  IM    
Affiliation:
Division of Clinical Neuroscience, St George's Hospital Medical School, University of London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Follow-Up Studies
Humans
Huntington Disease / genetics*,  radiography*
Male
Middle Aged
Tomography, X-Ray Computed
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