Document Detail


Humulone suppresses replication of respiratory syncytial virus and release of IL-8 and RANTES in normal human nasal epithelial cells.
MedLine Citation:
PMID:  23381605     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Respiratory syncytial virus (RSV) is the major infectious agent causing serious respiratory tract inflammation in infants and young children. However, an effective vaccine and anti-viral therapy for RSV infection have not yet been developed. Hop-derived bitter acids have potent pharmacological effects on inflammation. Therefore, we investigated the effects of humulone, which is the main constituent of hop bitter acids, on the replication of RSV and release of the proinflammatory cytokine IL-8 and chemokine RANTES in RSV-infected human nasal epithelial cells (HNECs). We found that humulone prevented the expression of RSV/G-protein, formation of virus filaments and release of IL-8 and RANTES in a dose-dependent manner in RSV-infected HNECs. These findings suggest that humulone has protective effects against the replication of RSV, the virus assembly and the inflammatory responses in HNECs and that it is a useful biological product for the prevention and therapy for RSV infection.
Authors:
Jun Fuchimoto; Takashi Kojima; Tamaki Okabayashi; Tomoyuki Masaki; Noriko Ogasawara; Kazufumi Obata; Kazuaki Nomura; Satoshi Hirakawa; Naoyuki Kobayashi; Tatsuro Shigyo; Shin-Ichi Yokota; Nobuhiro Fujii; Hiroyuki Tsutsumi; Tetsuo Himi; Norimasa Sawada
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-5
Journal Detail:
Title:  Medical molecular morphology     Volume:  -     ISSN:  1860-1499     ISO Abbreviation:  Med Mol Morphol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101239023     Medline TA:  Med Mol Morphol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Frontier Laboratories of Value Creation, Sapporo Breweries Ltd, Shizuoka, 425-0013, Japan.
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