| Humoral regulation of human leukemic progenitor cell cycle: the case for turning off the cell cycle. | |
| | |
MedLine Citation:
|
PMID: 3572205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Colony-forming cells of chronic myelocytic leukemia as well as acute nonlymphocytic leukemia in the resting state can be turned on and mobilized into cell cycle with exposure to leukocyte conditioned medium. In addition, evidence indicates that the leukemic colony-forming cells in cell cycle can be turned off and mobilized out of cell cycle by withholding the leukocyte conditioned medium. The system used in this study will be invaluable in biologic studies of leukemic cell cycling and its manipulation. With the concept of leukemic cell-cycle manipulation established, new approaches to treatment of leukemia based on growth manipulation should be explored. |
| | |
Authors:
|
C H Park |
Related Documents
:
|
15017265 - The cell cycle and its relevance to the urologist. 8224535 - Analysis of cell cycle progression during the development of dictyostelium and its rela... 10559915 - Four-dimensional control of the cell cycle. 17703085 - Deregulation of cell cycle machinery in pancreatic cancer. 402215 - Ultrastructural and immunohistochemical demonstration of pancreatic polypeptide-contain... 3123175 - Calibration of flow cytometric fluorescence standards using the isoparametric analysis ... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of laboratory and clinical medicine Volume: 109 ISSN: 0022-2143 ISO Abbreviation: J. Lab. Clin. Med. Publication Date: 1987 May |
Date Detail:
|
Created Date: 1987-06-01 Completed Date: 1987-06-01 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375375 Medline TA: J Lab Clin Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 571-4 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Cycle Cell Differentiation Cell Survival Culture Media Humans Leukemia / pathology* Neoplastic Stem Cells / pathology* |
| Grant Support | |
ID/Acronym/Agency:
|
K04 CA 00534/CA/NCI NIH HHS; R01 CA 20717/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Culture Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Protein origin of the volatile fatty acids isobutyrate and isovalerate in human stool.
Next Document: The phenomenon of leukergy: induction and detection of leukocyte aggregation in whole human blood.