Document Detail

Humoral regulation of cell-mediated immunity to syngeneic tumor.
MedLine Citation:
PMID:  953995     Owner:  NLM     Status:  MEDLINE    
Inoculation i.p. of C57BL/6 mice with FBL-3 cells, a syngeneic Friend virus-induced leukemia, results in progressive growth of ascitic tumors; in contrast, s.c. inoculation of FBL-3 cells produces transient, localized tumor growth; the recipients are then subsequently resistant to further i.p. challenge of this tumor. Experiments were performed to study the effects of humoral factors that might be present in the ascitic fluid and that could affect the growth of the tumors and the host immune response. It was found that ascitic fluids obtained from various murine tumors could indeed promote the s.c. growth of FBL-3 cells. Furthermore, administration of these ascitic fluids was found to suppress the induction of both the primary and secondary cell-mediated cytotoxic responses to FBL-3 cells in vivo and in vitro and to inhibit the effector phase of these cell-mediated cytotoxic reactions in vitro. These studies indicate that the ascitic fluids obtained from tumor-bearing hosts contain humoral factors that can promote tumor growth and suppress immune responses.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer research     Volume:  36     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1976-11-01     Completed Date:  1976-11-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3695-701     Citation Subset:  IM    
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MeSH Terms
Ascitic Fluid / immunology*
Cytotoxicity Tests, Immunologic
Friend murine leukemia virus
Immunity, Cellular*
Immunologic Memory
Leukemia, Experimental / immunology*
Mice, Inbred C57BL

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